Simulation of the L-phenylalanine production process by the fermentative route using SuperPro Designer® simulator

Simulación del proceso de producción de L-fenilalanina por la ruta fermentativa utilizando el simulador SuperPro Designer®

Published 2021-03-29

Proceso de producción de L-Fe por la ruta fermentativa
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Vol. 18 No. 35 (2021)
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Simulation of the L-phenylalanine production process by the fermentative route using SuperPro Designer® simulator. (2021). Revista EIA, 18(35), 35017 pp. 1-15. https://doi.org/10.24050/reia.v18i35.1417
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Amaury Perez Sanchez
Universidad de Camaguey
http://orcid.org/0000-0002-0819-6760
Elizabeth Ranero-González
Departamento de Ingeniería Química, Facultad de Ciencias Aplicadas, Universidad de Camagüey
Eddy J. Pérez-Sánchez
Empresa Servicios Automotores S.A.
Rutdali Maria Segura-Silva
Departamento de Investigación y Desarrollo, Centro de Ingeniería Genética y Biotecnología de Camagüey
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Amaury Perez Sanchez,

Departamento de Ingenieria Quimica, Profesor Instructor, Especialista Principal

L-phenylalanine (L-Phe) is one of the eight essential amino acids for the human body. In this work, the simulation of the L-Phe fermentative production process was carried out using the SuperPro Designer® simulator, in order to know its most important profitability indicators under the current economic conditions in Cuba. A sensitivity study was also accomplished with the objective of knowing from which value of the parameter unit selling price of an L-Phe bottle a positive value begins to be obtained of the indicator Net Present Value (NPV). A gross margin of 70.15%, a unit cost of production of USD $ 66.75 per bottle and a return on investment of 38.92% were obtained. From a value of the unit sale price of the L-Phe bottle of USD $ 115.3 the production plant starts to be profitable. The L-Phe production process can be considered profitable and feasible from the techno-economical point of view, based on the results obtained of NPV (USD $ 14,040,000), Internal Rate of Return (49.14%) and Payback Time (2.57 years).     

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