Computational Intelligence to Assess the Existence of Pain, Based on the Use of Electrophysiological Signals
Inteligencia computacional para la medición de presencia de dolor mediante el uso de señales electrofisiológicas


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Pain is a health problem that affects people physically and emotionally. To determine the
pain experimented, a survey is carried out, which implies self-evaluation, honesty, and
verbal or facial communication capability. In this paper, we present a comparison of two
computational algorithms for two classifiers: the first classifier discriminates between
pain and no pain, and the second one classifies three levels of pain. The algorithms
employed were the support vector machine (SVM) and a quadratic discriminant analysis
method (QDA). Acute pain was induced in fifteen participants by electrostimulation,
during the experiment we assessed electromyography (EMG), electrocardiography (ECG),
electrodermal activity (EDA), and electroencephalography (EEG), as well we asked the
participants to report their pain perception using the visual analog scale. Subsequently, we
extracted features related to pain assessment from the acquired signals. Three analyses
were performed, binary classifications with multiple features, binary classifications with
one feature, and three-level classifications with various features. We compared the SVM and
the QDA algorithms using the confusion matrix, and the computational cost. For the binary
classification, the SVM algorithm accuracy was 88.02% and the QDA algorithm accuracy was
70.78%, with a computational cost of 9.587 s and 3.023 s, respectively.
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- Bellmann P.; Schwenker F. (2020). Automated pain assessment: Is it useful to combine person-specific data samples?. 2020 IEEE Symposium Series on Computational Intelligence (SSCI), Caberra, ACT, Australia. pp. 1588–1593. DOI: 10.1109/SSCI47803.2020.9308279
- Breau L. (2010). The science of pain measurement and the frustration of clinical pain assessment: Does an individualized numerical rating scale bridge the gap for children with intellectual disabilities? PAIN. 150(2), pp. 213-214. DOI: 10.1016/j.pain.2010.03.029
- Briggs M.; Closs J. S. (1999). A descriptive study of the use of visual analogue scales and verbal rating scales for the assessment of postoperative pain in orthopedic patients. Journal of Pain and Symptom Management. 18(6), pp. 438–446. DOI: 10.1016/s0885-3924(99)00092-5.
- Díaz, R.; Marulanda, F. (2019). Dolor crónico nociceptivo y neuropático en población adulta de Manizales (Colombia). Acta Médica Colombiana, 36(1), pp. 10-17. DOI: 10.36104/amc.2011.151
- Christie S.; di Fronso S.; Bertollo M.; Werthner P. (2017). Individual alpha peak frequency in ice hockey shooting performance. Frontiers in Psychology. 8, p. 762. DOI: 10.3389/fpsyg.2017.00762
- Egede, J. O.; Song, S.; Olugbade, T. A.; Wang, C.; Williams, A. C. D. C.; Meng, H.; Aung, M.; Lane, N. D.; Valstar, M.; Bianchi-Berthouze, N. (2020). EMOPAIN challenge 2020: Multimodal pain evaluation from facial and bodily expressions. 2020 15th IEEE International Conference on Automatic Face and Gesture Recognition (FG), Buenos Aires, Argentina. pp. 849–856. DOI: 10.1109/FG47880.2020.00078
- Erdogan, B.; Ogul, H. (2020). Objective pain assessment using vital signs. Procedia Computer Science. 170, pp. 947–952. DOI:10.1016/j.procs.2020.03.103
- Hadjileontiadis, L. J. (2015). Eeg-based tonic cold pain characterization using wavelet higher order spectral features. IEEE Transactions on Biomedical Engineering. 62(8), pp. 1981–1991. DOI: 10.1109/TBME.2015.2409133
- Hadjileontiadis, L. J. (2018). Continuous wavelet transform and higher-order spectrum: combinatory potentialities in breath sound analysis and electroencephalogram-based pain characterization. Philosophical Transactions of The Royal Society a Mathematical, physical, and engineering sciences. 376 (2126). DOI: 10.1098/rsta.2017.0249
- Hassan, T.; Seuß, D.; Wollenberg, J.; Weitz, K.; Kunz, M.; Lautenbacher, S.; Garbas, J. U.; Schmid, U. (2021). Automatic detection of pain from facial expressions: A survey. IEEE Transactions on Pattern Analysis and Machine Intelligence. 43(6), pp. 1815–1831. DOI: 10.5121/ijcses.2012.3604. 47
- Hautala, A. J.; Karppinen, J.; Sepp ̈anen, T. (2016). Short-term assessment of autonomic nervous system as a potential tool to quantify pain experience. 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Orlando,FL, USA. pp. 2684–2687. DOI: 10.1109/EMBC.2016.7591283
- Hung, C.; Shen, T.; Liang, C.; Wu, W. (2014). Using surface electromyography (semg) to classify low back pain based on lifting capacity evaluation with principal component analysis neural network method. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society; Chicago, IL, USA. pp. 18–21. DOI: 10.1109/EMBC.2014.6943518
- Jollant, F.; Voegeli, G.; Kordsmeier, N. C.; Carbajal, J. M.; Richard-Devantoy, S.; Turecki, G.; Caceda, R. (2019). A visual analog scale to measure psychological and physical pain: A preliminary validation of the ppp-vas in two independent samples of depressed patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 90, pp.55–61. DOI: 10.1016/j.pnpbp.2018.10.018
- Kostyunina, M. B.; Kulikov, M. A. (1996). Frequency characteristics of eeg spectra in the emotions. Neuroscience and Behavioral Physiology. 26(4), pp. 340–343. DOI: 10.1007/BF02359037
- Lusher, J.; Elander, J.; Bevan, D.; Telfe,r P.; Burton, B. (2006). Analgesic addiction and pseudo-addiction in painful chronic illness. The Clinical Journal of Pain. 22(3). DOI: 10.1097/01.ajp.0000176360.94644.41
- Medrano, R.; Varela, A.; Domínguez, M.; PardM, G.; Acosta, Y.; Pardo, G. (2010). Aspectos epidemiológicos relacionados con el
- dolor en la población adulta. Revista Archivo Médico de Camagüey. 14(4). http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-02552010000400013&lng=es&tlng=es.
- Monroe, T. B.; Misra, S.; Habermann, R. C.; Dietrich, M. S.; Bruehl, S. P.; Cowan, R. L.; Newhouse, P. A.; Simmons, S. F. (2015). Specific physician orders improve pain detection and pain reports in nursing home residents: Preliminary data. Pain management nursing: official journal of the American Society of Pain Management Nurses. 16(5), pp. 770–780. DOI: 10.1016/j.pmn.2015.06.002
- Nir, R. R.; Sinai, A.; Raz, E.; Sprecher, E.; Yarnitsky, D. (2010). Pain assessment by continuous eeg: Association between subjective perception of tonic pain and peak frequency of alpha oscillations during stimulation and at rest. Brain research. 1344, pp. 77–86. DOI: 10.1016/j.brainres.2010.05.004
- Nisbet, G.; Sehgal, A. (2019). Pharmacology in the management of chronic pain. Anaesthesia and Intensive Care Medicine. 20(10), pp. 555 – 558. DOI:10.1016/j.mpaic.2019.07.009
- Nora D. (2014). America’s addiction to opioids: Heroin and prescription drug abuse. Pearson Educacion. Padmanabhan S, SindhuG. 2014. Design of an ecg acquisition device for the nonlinear analysis of heart rate variability (hrv). 02
- Petrovic, P.; Petersson, K. M.; Ghatan, P.; Stone-Elander, S.; Ingvar, M. (2000). Pain-related cerebral activation is altered by a distracting cognitive task. Pain. 85, pp. 19–30. DOI: 10.1016/s0304-3959(99)00232-8
- Pikulkaew, K.; Chouvatut, V. (2021). Enhanced pain detection and movement of motion with data augmentation based on deep learning. 2021 13th International Conference on Knowledge and Smart Technology (KST), Bangsaen, Chounburi, Thailand. pp. 197–201. DOI: 10.1109/KST51265.2021.9415827
- Pouromran, F.; Radhakrishnan, S.; Kamarthi S. (2021). Exploration of physiological sensors, features, and machine learning models for pain intensity estimation. PLoS One. 16(7). DOI: 10.1371/journal.pone.0254108
- Lo Presti, L.; La Cascia, M. (2017). Boosting hankel matrices for face emotion recognition and pain detection. Computer Vision and Image Understanding. 156, pp.19–33. DOI: 10.1016/J.CVIU.2016.10.007
- Rathee, N.; Ganotra, D. (2015). A novel approach for pain intensity detection based on facial
- feature deformations. Journal of Visual Communication and Image Representation. 33, pp. 247 -254. DOI: 10.1016/J.JVCIR.2015.09.007
- Rodriguez, P.; Cucurull, G.; González, J.; Gonfaus, J. M.; Nasrollahi, K.; Moeslund, T. B.; Roca, F. X. (2022). Deep pain: Exploiting long short-term memory networks for facial expression classification. IEEE Transactions on Cybernetics. 52(5), pp. 3314-3324. DOI: 10.1109/TCYB.2017.2662199
- Rojo, R.; Prados-Frutos, J. C.; López-Valverde, A. (2015). Pain assessment using the facial action coding system. A systematic review. Medicina Clínica (English Edition). 145(8), pp. 350–355. DOI: 10.1016/j.medcli.2014.08.010
- Roy, S. D.; Bhowmik, M. K.; Saha, P.; Ghosh, A. K. (2016). An approach for automatic pain detection through facial expression. Procedia Computer Science. 84, pp. 99–106. DOI:10.1016/j.procs.2016.04.072
- Rupenga, M.; Vadapalli, H. B. (2016). Automatic spontaneous pain recognition using supervised classification learning algorithms. 2016 Pattern Recognition Association of South Africa and Robotics and Mechatronics International Conference (PRASA-RobMech), South Africa, Stellenbosch. IEEE. pp. 1-6. DOI:10.1109/ROBOMECH.2016.7813150
- Siqueira, S. R. D. T.; de Siqueira, J. T. T. T.; Teixeira, M. J. (2020). Chronic pain, somatic unexplained complaints and multimorbidity: A mutimorbidity painful syndrome?. Medical Hypotheses. 138, p. 109598. DOI: 10.1016/j.mehy.2020.109598.
- Stahlschmidt, L.; Friedrich, Y.; Zernikow, B.; Wager, J. (2018). Assessment of pain-related disability in pediatric chronic pain: A comparison of the functional disability inventory and the pediatric pain disability index. Clinical Journal of Pain. 34 (2), pp. 1173-1179. DOI: 10.1097/AJP.0000000000000646
- Subramaniam, S. D.; Dass, B. (2021). Automated nociceptive pain assessment using physiological signals and a hybrid deep learning network. IEEE Sensors Journal. 21(3), pp. 3335–3343. DOI: 10.1109/JSEN.2020.3023656.
- Susam, B.; Akcakaya, M.; Nezamfar, H.; Diaz, D.; Xu, X.; de Sa, V.; Craig, K.; Huang, J.; Goodwin, M. (2018). Automated pain assessment using electrodermal activity data and machine learning. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Honolulu, HI, USA. IEEE Sensors Journal, pp. 372–375. DOI: 10.1109/JSEN.2020.3023656.
- Susam, B. T.; Riek, N. T.; Akcakaya, M.; Xu, X.; de Sa,, V. R.; Nezamfar, H.; Diaz, D.; Craig, K. D.; Good-win, M. S.; Huang, J. S. (2022). Automated pain assessment in children using electrodermal activity and video data fusion via machine learning. IEEE Transactions on Biomedical Engineering. 69(1), pp. 422–431. DOI: 10.1109/TBME.2021.3096137
- Thiam, P.; Hihn, H.; Braun, D.A.; Kestler, H.A.; Schwenker, F. (2021). Multi-modal pain intensity assessment based on physiological signals: A deep learning perspective. Frontiers in Physiology. 12. https://doi.org/10.3389/fphys.2021.720464
- Van, A. J.; Van den, W. (2015). The misuse of prescription opioids: A threat for Europe? Current Drug Abuse Reviews, 8(1), pp. 3–14. DOI: 10.2174/187447370801150611184218
- Wang, R.; Xu, K.; Feng, H.; Chen, W. (2020). Hybrid RNN-ANN based deep physiological network for pain recognition. 42nd Annual International Conference of the IEEE Engineering in Medicine Biology Society (EMBC), Montreal, QC, Canada. Institute of Electrical and Electronics Engineers (IEEE), pp. 5584–5587. DOI: 10.1109/EMBC44109.2020.9175247.
- Wong, T.T.; Yeh, P.Y. (2020). Reliable accuracy estimates from fold cross validation. IEEE Transactions on Knowledge and Data Engineering. 32(8):1586–1594. DOI: 10.1109/TKDE.2019.2912815
- Yang, F.; Banerjee, T.; Panaggio, M. J.; Abrams, D. M.; Shah, N.R. (2019). Continuous pain assessment using ensemble feature selection from wearable sensor data. 2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), San Diego, CA, USA, Institute of Electrical and Electronics Engineers (IEEE), pp. 569–576. DOI: 10.1109/BIBM47256.2019.8983282