ENGINEERING MATERIALS SURFACES BY MICROFABRICATION TECHNIQUES, TO REGULATE IN VITRO CELL FUNCTIONS: REVIEW
ENGINEERING MATERIALS SURFACES BY MICROFABRICATION TECHNIQUES, TO REGULATE IN VITRO CELL FUNCTIONS: REVIEW
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It has been clear that the surface properties of the materials used as substrates for cell culture can influence the cell behavior affecting different factors such as cell orientation, adhesion, growth, differentiation, and apoptosis. In the last few years, several micro and nanofabrication techniques have emerged as important tools used to modify the surface properties of those materials at the micro or nano scale, topologically or chemically. This paper reviews the most used microfabrication techniques to introduce modifications on the materials surfaces and its implications on cell behavior. This review ends up showing the possible medical applications derived as a source of future work in the field.
Resumen: Ha quedado claro que las propiedades superficiales de los materiales utilizados como sustratos para cultivo celular pueden influir en el comportamiento de las células afectando diferentes factores tales como la orientación celular, adhesión, crecimiento, diferenciación y apoptosis. En los últimos años, varias técnicas de microfabricación y nanofabricación han emergido como herramientas importantes usadas para modificar las propiedades superficiales de esos materiales en la escala micrométrica y nanométrica, ya sea topográfica o químicamente. Este artículo revisa las técnicas de microfabricación mas usadas para introducir modificaciones en las superficies de los materiales y sus implicaciones en el comportamiento celular. Esta revisión termina mostrando las posibles aplicaciones médicas derivadas como una fuente de futuros desarrollos en este campo.
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